What Is 7OH? Understanding 7-Hydroxymitragynine, Kratom’s Most Potent Alkaloid
In recent years, kratom has experienced a rapid rise in popularity across the United States, fueled by its accessibility, legal gray area, and bold marketing as a natural remedy. Sold in smoke shops, wellness stores, and countless online marketplaces, kratom is often billed as an herbal supplement capable of relieving pain, boosting mood, increasing energy, and even acting as an alternative to prescription opioids. For many users, it’s seen as a “safer,” plant-based solution to chronic pain, anxiety, or opioid withdrawal. But behind kratom’s earthy packaging and wellness branding lies a far more potent—and misunderstood—chemical reality.
What most consumers don’t realize is that kratom’s most powerful effects are driven by a single, highly active compound: 7-hydroxymitragynine, commonly known as 7OH. While it exists in only trace amounts in the plant itself, 7OH is incredibly potent—far more so than the better-known alkaloid mitragynine—and has a profound impact on the body’s opioid receptors.
In fact, 7OH is the primary reason kratom feels like an opioid, and why some users find themselves developing dependence, tolerance, and withdrawal symptoms despite initially viewing the substance as benign or even therapeutic.
So what exactly is 7OH? How does it work, how strong is it compared to morphine, and what are the real risks—both short-term and long-term? Is it technically an opioid, and if so, how does it differ from substances like oxycodone or heroin? Can it lead to addiction? Does it show up on drug tests?
In this in-depth article, we’ll unpack everything you need to know about 7-hydroxymitragynine—from its chemical structure and mechanism of action to its role in kratom’s effects, its legal status, and its implications for treatment and recovery. Whether you’re a concerned family member, a healthcare provider, or someone using kratom yourself, understanding 7OH is critical to seeing the full picture—not just the marketing claims.
Table of Contents
What is 7OH?
How Is 7OH Related to Kratom?
Is 7OH Stronger Than Morphine?
Is 7-Hydroxymitragynine an Opioid?
What Does 7-Hydroxymitragynine Do to You?
Is 7OH an Opioid Agonist?
Why Is 7OH So Controversial?
7OH and the Risk of Addiction
7OH in Drug Testing and Clinical Settings
Legal Status and Regulatory Oversight
7OH and Harm Reduction: What Should Users Know?
Treatment for Kratom and 7OH Dependence
Final Thoughts: What Does the Future Hold?
1. What is 7OH?
7-Hydroxymitragynine (7OH) is one of more than 40 naturally occurring alkaloids found in the leaves of the kratom plant (Mitragyna speciosa), a tropical tree native to Southeast Asia. While the plant contains a variety of bioactive compounds, 7OH stands out as the most pharmacologically potent, particularly when it comes to its psychoactive and opioid-like properties. Structurally, it is closely related to mitragynine, kratom’s most abundant alkaloid, but far more powerful. In fact, 7OH is not originally present in large amounts in the raw plant—it is typically formed as a metabolite when mitragynine is processed by the human liver after ingestion.
Chemically speaking, 7OH is considered a semi-synthetic derivative of mitragynine due to its transformation via enzymatic activity in the body. Though it makes up only a tiny fraction of the kratom leaf’s overall composition—usually less than 0.05% by weight—its impact on the brain’s opioid receptors is disproportionately large. In practical terms, this means that most of kratom’s well-known effects—such as pain relief, sedation, and euphoria—are not directly caused by mitragynine itself, but by the 7OH that’s formed once it enters the bloodstream.
As a result, 7OH is often considered the true engine behind kratom’s narcotic-like effects, making it the focal point of both scientific research and growing public health concerns.
2. How Is 7OH Related to Kratom?
When kratom is consumed—especially in dried or powdered form—its dominant alkaloid, mitragynine, is metabolized by the liver into 7-hydroxymitragynine. This transformation enhances the pharmacological activity of kratom and is largely what gives the substance its euphoric, analgesic, and sedative properties.
That means that even if a kratom product contains low levels of 7OH directly, your body still ends up producing it internally.
Some manufacturers have even begun to synthetically enhance 7OH levels in kratom extracts, leading to products far more powerful—and potentially dangerous—than the natural plant.
3. Is 7OH Stronger Than Morphine?
Yes—7OH is significantly stronger than morphine when measured by receptor affinity and potency.
Animal studies have demonstrated that 7-hydroxymitragynine can be 13 to 46 times more potent than morphine in terms of analgesic effect. That doesn’t mean it produces the exact same high or duration of effects, but in terms of binding to the mu-opioid receptor, it’s extremely powerful.
It's important to note that potency doesn’t always equate to danger in a straightforward way. However, the fact that such a small dose of 7OH can have a morphine-like impact makes it a key concern for health professionals.
4. Is 7-Hydroxymitragynine an Opioid?
The short answer: Yes, 7OH is an opioid alkaloid.
While it’s structurally different from traditional opioids like oxycodone or heroin, it binds to the same opioid receptors in the brain, particularly the mu-opioid receptor, which is responsible for euphoria, pain relief, and respiratory depression.
The term “opioid” doesn’t refer solely to substances derived from opium poppies. It includes any substance, synthetic or natural, that acts on opioid receptors. By that definition, 7OH qualifies.
However, it’s sometimes referred to as an "atypical opioid" because of its mixed pharmacology and its reputation for causing fewer respiratory depressant effects than traditional opioids—though this claim is debated and not yet proven in human trials.
5. What Does 7-Hydroxymitragynine Do to You?
When consumed, 7OH has a range of effects that vary by dose, individual biology, and whether it’s being taken with other substances. Some of the most common effects include:
Pain relief
Mild to moderate euphoria
Increased energy or sedation (depending on dose)
Reduced anxiety
Suppressed appetite
Nausea or dizziness
Constipation
Dependence and withdrawal with repeated use
In small doses, kratom (and therefore 7OH) can act more like a stimulant. At higher doses, it mimics traditional opioids more closely, providing a sedating, numbing experience.
6. Is 7OH an Opioid Agonist?
Yes, 7OH is a partial opioid agonist—specifically at the mu-opioid receptor.
That means it binds to the receptor and activates it, but not to the same extent as full agonists like fentanyl or heroin. This partial activity is what has led some to claim that 7OH is “safer,” but the reality is more complex.
Partial agonists can still cause tolerance, dependence, and withdrawal, especially when used regularly or at high doses. And depending on the formulation, some kratom products with elevated 7OH content can mimic the effects of full agonists quite closely.
7. Why Is 7OH So Controversial?
The controversy around 7OH boils down to three things:
Potency: Despite being marketed as “natural,” kratom extracts with high 7OH content are pharmacologically similar to synthetic opioids.
Lack of regulation: Because kratom is not federally scheduled in the U.S., companies can manufacture highly concentrated products with little oversight.
Addiction risk: People turn to kratom thinking it’s a safe alternative—but find themselves facing full-blown opioid withdrawal months later.
While 7OH might not show up on a standard drug test, its effects can absolutely mimic those of Schedule II opioids, leading to misuse, dependence, and even overdose—especially when combined with alcohol or benzodiazepines.
8. 7OH and the Risk of Addiction
Research shows that 7-hydroxymitragynine has a high abuse potential due to its rapid onset and strong binding at opioid receptors.
Users often report:
Increased tolerance over time
Need to escalate doses to achieve the same effects
Withdrawal symptoms like sweating, insomnia, anxiety, and muscle aches
Difficulty stopping despite wanting to
While kratom withdrawal is typically milder than that of heroin or fentanyl, it can still be physically and psychologically intense, especially for heavy users.
7OH Tolerance: A Hidden Risk of Regular Use
One of the most critical and under-discussed risks of 7-hydroxymitragynine is the rapid development of 7OH tolerance. As users consume 7OH—especially in purified or enhanced forms like tablets, tinctures, or concentrated extracts—the brain begins to adapt quickly. Over time, the same dose produces weaker effects, leading many to increase their intake to recapture the original relief or euphoria.
This escalating pattern is a hallmark of physical dependence. Unlike traditional kratom leaf, which contains a broader spectrum of alkaloids and may build tolerance more slowly, pure 7OH products often lead to noticeable tolerance within just a few days or weeks. The result is a cycle of increasing dosage, shortened duration of effect, and a much harder comedown when use stops.
For individuals using 7OH for pain, anxiety, or opioid withdrawal relief, this tolerance can be especially dangerous—it masks the drug’s potency and increases the risk of dependence without users realizing how far they’ve drifted. Once 7OH tolerance is established, stopping use can bring on withdrawal symptoms that mirror those of traditional opioids.
How Long Does 7OH Take to Kick In?
The onset time for 7-hydroxymitragynine (7OH) depends on the method of ingestion and individual metabolism, but in most cases, 7OH kicks in within 15 to 30 minutes when taken orally.
Products like OPiA 7-Hydroxy chewable tablets are absorbed through the digestive system, leading to a slightly delayed but more controlled onset compared to liquid extracts or sublingual tinctures. Some users report feeling initial effects as early as 10 minutes in, especially on an empty stomach, while others may not feel the full impact until the 30–45 minute mark.
Because 7OH is a highly potent opioid receptor agonist, its effects tend to escalate quickly once absorption begins. Users often describe a sudden wave of warmth, sedation, or euphoria—not unlike the onset of a short-acting prescription opioid.
Keep in mind: the faster the onset, the higher the abuse potential, especially for individuals chasing rapid relief or a quick high. This makes awareness of onset time critical for harm reduction.
7OH Dosage: How Much Is Too Much?
Because 7-hydroxymitragynine (7OH) is an isolated, highly potent compound, dosage matters more than most users realize. Unlike raw kratom leaf, which contains a broader mix of alkaloids in lower concentrations, pure 7OH delivers direct opioid receptor activation in small amounts—making it far easier to overdo.
For context:
Low dose: 1–3 mg
Moderate dose: 4–8 mg
High dose: 10–20+ mg
Extreme dose: 20 mg and above, especially in extract or tablet form (e.g., OPiA 7-Hydroxy)
Most users report noticeable opioid-like effects starting at just 2–4 mg, especially in individuals with little or no prior opioid tolerance. At 10 mg and above, 7OH can produce sedation, respiratory depression, nausea, and other side effects typical of full opioid agonists.
Branded products like OPiA contain 20 mg per chewable tablet, placing them firmly in the high-dose category—particularly if more than one tablet is used at a time.
Because of its potency and addictive potential, daily use or redosing is strongly discouraged, especially outside of medical oversight. Tolerance builds quickly, and even small increases in dose can result in a dramatic shift in both intensity and risk.
9. 7OH in Drug Testing and Clinical Settings
7OH does not usually appear on standard opioid drug panels, which leads many people to falsely believe it’s undetectable or harmless.
However, specialized tests do exist and can detect both mitragynine and 7-hydroxymitragynine in urine or blood samples. Some addiction treatment centers and hospitals are now incorporating kratom-specific panels into their screenings, especially in cases of unexplained withdrawal or overdose.
Clinically, kratom use is still under-documented. Many patients don't disclose it due to its legal status or the perception that it’s “just a supplement.” That makes it harder for providers to identify 7OH-related complications.
10. The Legal Gray Zone: 7OH Regulation and Widespread Retail Access
As of 2025, kratom remains legal at the federal level in the U.S., though several states and cities have enacted bans.
The FDA has issued multiple warnings about kratom, and the DEA has considered—but not finalized—a move to classify mitragynine and 7OH as Schedule I substances. This has been met with heavy public and political pushback, largely due to concerns around chronic pain and harm reduction.
The bottom line? 7OH is largely unregulated, especially in extract form, and that’s where most of the risk lies. One of the more popular and accessible products is discussed below.
OPiA 7-Hydroxy: High-Purity 7OH in a Chewable Form—At What Cost?
As kratom extracts grow in popularity, new branded products are entering the market—offering stronger, cleaner, and more targeted versions of compounds like 7-hydroxymitragynine. One of the most widely recognized examples is OPiA 7-Hydroxy, a chewable tablet formulation that delivers pharmaceutical-style dosing of one of kratom’s most potent alkaloids.
Each OPiA tablet contains 20mg of high-purity 7-hydroxymitragynine, precisely measured and scored for controlled use. A single pack provides 80mg of 7OH across eight servings—packaged in a way that resembles over-the-counter supplements or wellness products. Marketed toward "veteran users," the product highlights its natural ingredients, convenient dosing, and clean formulation. What it doesn’t emphasize is the clinical potency of 7OH—or the significant risks that come with easy access to such a powerful opioid agonist.
The appeal of OPiA 7-Hydroxy is clear: it offers a concentrated, predictable experience, without the mess of powders or variability of leaf-based kratom. But that same convenience is what makes it so concerning. With no prescription required, no age verification in many cases, and virtually no regulatory oversight, users can purchase a near-opioid-level substance online and consume it casually—often without fully understanding its strength or addictive potential.
Products like OPiA represent a new frontier of kratom-derived substances: highly potent, easily consumed, and disturbingly normalized. While the packaging might suggest wellness or sophistication, the reality is that each chewable tablet can deliver effects far stronger than most prescription opioids. For individuals with low tolerance or a history of substance use, a single pack can easily lead to unexpected sedation, respiratory depression, or a fast onset of physical dependence.
What makes OPiA even more problematic is its growing popularity on Reddit forums, YouTube reviews, and influencer spaces, where users often post glowing testimonials with little regard for the long-term risks. There’s a trend emerging: as people shift away from traditional opioids, they’re turning to kratom extracts like OPiA for “legal highs” or withdrawal support—unaware that they may be walking straight into a new dependency.
As more branded 7OH products flood the market, the need for public education, medical awareness, and early intervention grows. Families and clinicians should be aware that products like OPiA aren't just another herbal supplement—they’re potent, opioid-acting substances dressed in a more palatable form.
7OH Syrup: The New Frontier of Kratom Extracts
As kratom products evolve, one of the newest and most potent forms gaining popularity is 7OH syrup—a concentrated liquid extract formulated to deliver high doses of 7-hydroxymitragynine in a sweetened, drinkable format. Marketed as a fast-acting, flavorful option for experienced users, these syrups typically contain measured amounts of pure 7OH per bottle or serving, often well beyond what’s found in traditional kratom powders or capsules.
The appeal is obvious: rapid onset, easy dosing, and no need to swallow pills or mix powders. But the risks are just as clear. 7OH syrup allows users to consume dangerously high amounts of an already potent opioid-like compound—often without realizing how much they’re taking. Some products are labeled vaguely, while others fail to specify the exact concentration of 7-hydroxymitragynine per milliliter, making it easy to misjudge a dose.
In many cases, a single bottle of 7OH syrup can contain 50mg to 100mg or more of active 7OH, placing even casual users at risk for respiratory depression, sedation, and rapid tolerance. Because syrups are liquid, they’re more easily absorbed than capsules or tablets, which means effects can hit harder and faster, mimicking the pharmacokinetics of short-acting opioids.
Another concern is ease of concealment. Unlike raw kratom or tablets, syrup can be mixed into drinks or stored inconspicuously, making it more appealing to younger users or those trying to hide their consumption.
For treatment providers and families, 7OH syrup represents a serious escalation in kratom product potency and misuse potential. It’s not just a different form—it’s a fundamentally higher-risk delivery system that can lead to dependency faster, intensify withdrawal symptoms, and increase the likelihood of polydrug use.
If someone is using 7OH syrup regularly—or escalating doses to maintain the same effect—it may be time to step in and address the deeper issue. Syrup formulations may seem less threatening, but the clinical risks are no different than those of other opioid analogs.
7-OH Vapes: Fast-Acting, High-Risk, and Lightly Regulated
As the kratom market evolves, one of the newest and most concerning trends is the emergence of 7-OH vapes—vaporizer cartridges or disposable pens containing vape-form 7-hydroxymitragynine. These products are designed to deliver ultra-fast onset, bypassing digestion and delivering the alkaloid directly into the bloodstream through the lungs.
While marketed as convenient and “cleaner” alternatives to powders or syrups, 7-OH vapes amplify every risk associated with this compound. Vaping allows for near-instant activation of opioid receptors, making the rush more intense and the cycle of redosing more compulsive. For users chasing fast relief or a rapid high, this delivery system can lead to dependence in a much shorter time frame than oral forms.
Another danger: dosing is far less predictable. Unlike tablets or measured syrups, vapes often don’t disclose exact concentrations of 7OH, and absorption rates vary widely by device and user. Add to that the risk of contamination, vitamin E acetate, or synthetic additives, and you’re looking at a product with high abuse potential and minimal transparency.
7-OH vapes are also harder to detect. They produce little odor, resemble nicotine devices, and can be used discreetly in schools, workplaces, or treatment settings—making them particularly risky for younger or high-acuity users.
At this point, no federal regulations explicitly address 7OH in vape form, meaning these products often fly under the radar of enforcement agencies and healthcare providers. That leaves consumers exposed to a highly potent opioid-like substance with no quality control, no usage guidelines, and no accountability.
Kama 7-Hydroxymitragynine: Branded Strength Without Guardrails
Kama 7-hydroxymitragynine is another rising name in the world of high-purity kratom extracts, offering users a fast-acting, concentrated form of 7OH—often marketed as an elite, premium product. Whether in tablet, capsule, or liquid extract form, Kama products are specifically designed for experienced kratom users looking for “enhanced effects,” meaning they contain elevated doses of 7OH, often without clear warnings or adequate dosage guidance.
What makes Kama 7OH products particularly concerning is the casual branding and ease of access. Sold online and in some retail shops, these extracts are frequently positioned as wellness or performance enhancers—but they function much more like opioid-class substances in how they act on the brain and body. With little regulatory oversight, consumers are left on their own to navigate the potency, side effects, and real risks of dependency.
While Kama claims to use “clean” ingredients and natural formulation processes, the reality is that no standardized testing or manufacturing controls exist for 7OH content. One batch may produce mild euphoria; another might result in overwhelming sedation or withdrawal symptoms with repeated use.
Clinicians, families, and recovery professionals should be aware that Kama and similar brands are not just stronger kratom—they’re vehicles for concentrated 7OH delivery, and they carry all the risks that come with high-affinity opioid receptor activity.
11. 7OH and Harm Reduction: What Should Users Know?
Using kratom—especially enhanced extracts with high concentrations of 7-hydroxymitragynine (7OH)—can be dangerous and damaging to your health. These products are not regulated, and their potency can vary drastically, increasing the likelihood of serious side effects or overdose.
Daily use is risky: Dependence can develop quickly, leading to withdrawal symptoms similar to opioids.
Mixing is deadly: Combining kratom with alcohol, benzodiazepines, or opioids significantly raises the risk of respiratory depression and fatal overdose.
Potency is unpredictable: High-concentration extracts may trigger adverse reactions even at small doses.
Medical complications are common: Failing to disclose kratom use can result in dangerous drug interactions or misdiagnosis.
Withdrawal is real: Nausea, sweating, tremors, insomnia, and anxiety may signal physical dependence.
Kratom is often marketed as a “natural” alternative—but that doesn’t mean it’s safe. In high doses or chronic use, especially when mixed with other substances, it can be every bit as harmful as the drugs it claims to replace.
12. Treatment for Kratom and 7OH Dependence
Treating kratom or 7OH dependence follows many of the same principles as opioid use disorder:
Medical detox for moderate to severe withdrawal symptoms
Recovery coaching to build new structure and reduce risk of relapse
Outpatient treatment or IOP for behavioral health support
MAT (Medication-Assisted Treatment) is still under-studied for kratom, but some providers use buprenorphine off-label
Family support and education to reduce enabling and improve outcomes
At Solace Health Group, we’ve supported many individuals who were blindsided by how quickly their kratom use escalated. Just because it’s legal doesn’t mean it’s safe—especially when high 7OH content is involved.
13. Final Thoughts: What Does the Future Hold?
7-hydroxymitragynine, or 7OH, is a chemically potent and deeply controversial compound. Though it originates from a natural source—the kratom plant—its pharmacological behavior closely mirrors that of high-strength opioids. In many cases, 7OH binds to opioid receptors with even greater affinity than morphine, making it both powerful and potentially dangerous. What makes 7OH particularly concerning is how easily it hides in plain sight: marketed as a harmless herbal supplement, cloaked in the language of wellness, and often consumed by individuals who have no idea they’re ingesting something with morphine-like potency.
The current landscape is a dangerous mix: minimal federal regulation, inconsistent product labeling, and widespread misinformation. Kratom products can vary drastically in alkaloid content from one batch to another, especially with concentrated extracts. Despite this, they continue to be sold over the counter or online with little oversight. Many consumers are misled by the "natural" label, assuming safety and underestimating the potential for dependence, withdrawal, and long-term health consequences. Some individuals use kratom and 7OH in a genuinely therapeutic way—seeking relief from chronic pain or using it to taper off traditional opioids. But for many others, what begins as harm reduction quietly becomes a new addiction.
As clinical research expands and more case studies emerge, the picture of 7OH is becoming clearer—and more sobering. Medical professionals are beginning to see the downstream effects: hidden dependencies, complicated withdrawals, and emergency room visits that defy standard toxicology panels. Families are starting to recognize the warning signs in loved ones who never touched heroin or fentanyl, yet display unmistakable symptoms of opioid use disorder. And public health agencies are slowly catching up, weighing whether kratom and its active compounds should be subject to tighter controls.
In the coming years, we expect to see more targeted interventions for 7OH-related dependence, more precise treatment protocols for kratom withdrawal, and stronger education around what this compound actually does. The conversation is shifting—from casual supplement talk to serious clinical concern.
Until that shift becomes mainstream, awareness remains the most important tool we have. Understanding what 7OH is, how it functions, and what it can lead to is no longer just academic—it’s essential for prevention, informed choice, and recovery.
Solace Health Group conducts thorough research, includes trusted citations, and ensures all content is reviewed for accuracy. However, this article is not medical advice and should not replace professional evaluation or treatment. Always consult a licensed healthcare provider before making any medical or treatment decisions.
Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657101/
https://www.dea.gov/sites/default/files/2020-06/Kratom-2020.pdf
https://www.fda.gov/news-events/public-health-focus/fda-and-kratom
https://pubmed.ncbi.nlm.nih.gov/27929538/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678724/
https://www.verywellmind.com/what-is-kratom-4177751
https://www.frontiersin.org/articles/10.3389/fphar.2022.822940/full
https://jamanetwork.com/journals/jama/fullarticle/2792434
https://www.sciencedirect.com/science/article/pii/S0378874117316393
https://nida.nih.gov/research-topics/kratom
