Kratom Use Disorder & The Detox Process
Written by: Benjamin Gift, CADC I
Reviewed by: Candice Watts, Clinical Director CADC II
Kratom is a tropical tree native to Southeast Asia, with leaves that contain compounds producing both stimulant and opioid-like effects. Traditionally used in countries like Thailand and Malaysia for pain relief, energy, and mood enhancement, kratom has gained popularity in the U.S. as an herbal supplement. However, despite its natural origin, kratom can be highly addictive. Regular use can lead to physical dependence, withdrawal symptoms, and compulsive behavior similar to that seen with other opioids. As its availability grows, so does the concern around kratom addiction and its impact on individuals seeking relief from pain, anxiety, or substance withdrawal.
Kratom Use: Patterns and Reported Effects
Kratom leaves contain alkaloids like mitragynine and 7-hydroxymitragynine, which interact with opioid receptors in the brain. Users typically consume it as powder, capsules, tea, or extracts11114. Kratom affects the brain and body in ways that vary depending on the dose. At lower doses, it typically acts as a stimulant, increasing energy, alertness, and sociability. At higher doses, however, kratom has sedative and opioid-like effects, producing feelings of euphoria, pain relief, and relaxation. Some users describe a sense of calm or emotional numbness, while others report heightened mood or a sense of well-being. Despite these effects, kratom can also cause nausea, dizziness, constipation, and confusion. Over time, frequent use may lead to tolerance, dependence, and withdrawal symptoms such as irritability, anxiety, muscle aches, and insomnia.
Reasons for Use
Stimulant effects (low doses): Increased energy, alertness, and sociability11216.
Sedative effects (high doses): Pain relief, relaxation, and reduced anxiety1314.
Self-treatment: Some use kratom to manage chronic pain, opioid withdrawal, or mental health conditions like depression91116.
Despite anecdotal benefits, the FDA and DEA emphasize that kratom is not approved for medical use due to safety risks, including addiction, contamination, and severe side effects91114.
Short-Term Risks
Physical symptoms: Nausea, sweating, rapid heartbeat, constipation, and dizziness31215.
Psychological effects: Agitation, confusion, hallucinations, and mood swings314.
Overdose potential: Rare but linked to respiratory depression, seizures, and liver toxicity39.
Kratom Addiction: Signs and Symptoms
Regular kratom use can lead to tolerance and dependence, with withdrawal symptoms resembling opioid withdrawal41214. Kratom addiction signs can develop gradually, especially with frequent or high-dose use, and is often marked by both physical and psychological symptoms. Common signs of kratom addiction include increased tolerance—needing more of the substance to achieve the same effects—and withdrawal symptoms when not using, such as anxiety, irritability, insomnia, muscle aches, and nausea. Behavioral changes may also occur, including compulsive use despite negative consequences, social withdrawal, neglect of responsibilities, and an intense focus on obtaining and using kratom. Some individuals may struggle to stop using even when they genuinely want to, which is a hallmark sign of addiction.
If you're new to this substance, you might be asking, how long does kratom take to kick in? For most users, the effects begin within 10 to 30 minutes after ingestion, depending on factors like dosage, body weight, metabolism, and whether it's taken on an empty stomach. When consumed in capsule form or with food, it may take slightly longer to feel the effects. Understanding how long does kratom take to kick in is important not only for managing expectations but also for avoiding the risk of taking more too soon, which can lead to unpleasant side effects or potential overdose. Always use caution and stay informed to ensure safe and responsible use.
Physical Signs of Addiction
Constricted pupils, tremors, excessive sweating, and gastrointestinal distress412.
Sleep disturbances, weight loss, and hyperpigmentation (with chronic use)416.
Nausea and vomiting
Constipation
Sweating (especially excessive sweating)
Itchy skin
Muscle aches or body pain
Behavioral and Psychological Indicators
Failed attempts to quit despite recognizing negative consequences412.
Prioritizing kratom use over social, occupational, or personal responsibilities12.
Mood swings, irritability, and heightened risk-taking (e.g., polysubstance use)412.
If you or a loved one is seeking compassionate, professional support on the journey to recovery, Solace Health offers personalized addiction services—from detox coordination to sober coaching—tailored to meet your unique needs. Let our experienced team help guide you toward lasting healing and freedom.
Kratom Withdrawal and Treatment Options
Kratom withdrawal can be challenging and shares similarities with opioid withdrawal, though its severity varies based on usage patterns, dosage, and individual physiology. Symptoms typically begin within 6 to 12 hours after the last dose and can last up to a week, with the most intense effects occurring around days 2 to 3. Early symptoms often include anxiety, agitation, muscle aches, and sweating. As withdrawal progresses, individuals may experience nausea, vomiting, diarrhea, insomnia, runny nose, and strong cravings. Psychological symptoms like depression, mood swings, and irritability are also common and may persist longer than physical symptoms. While kratom withdrawal is rarely life-threatening, it can be extremely uncomfortable and may require professional support to manage safely and effectively.
Medical Detox Programs
Inpatient detox: Provides 24/7 supervision, medications (e.g., buprenorphine for cravings), and IV hydration6813.
Outpatient detox: Suitable for mild cases, with regular check-ins and counseling710.
Rapid detox: Hospital-based sedation to minimize withdrawal intensity, though not widely standardized13.
Holistic and Supportive Therapies
Nutrition: Bland diets, hydration, and vitamins to address deficiencies1013.
Mind-body practices: Yoga, meditation, and aromatherapy to reduce stress10.
Behavioral therapies: Cognitive-behavioral therapy (CBT) to address triggers78.
Risks of At-Home Detox
High relapse rates due to intense cravings and lack of support1013.
Potential for exacerbated symptoms (e.g., dehydration from vomiting)510.
Regulatory and Safety Considerations
Contamination risks: Kratom products may contain heavy metals, bacteria, or synthetic additives915.
Legal status: Banned in some U.S. states and cities, though federally unregulated214.
Healthcare guidance: The FDA advises against kratom use, promoting FDA-approved treatments for pain and opioid use disorder instead911.
After Detox: The Importance of Ongoing Treatment
Detox is only the first step in recovery. While it addresses physical dependence, it does not treat the underlying addiction or the psychological and behavioral aspects of Kratom use disorder12. Without further treatment, relapse rates are high-up to 80% within the first month post-detox if no ongoing support is provided12. If you're searching for guidance on how to get off kratom, you're not alone—many individuals struggle with kratom dependence and are looking for safe, effective ways to quit. The best approach often includes a gradual taper, medical supervision, and support from addiction professionals who understand the unique challenges of kratom withdrawal. Quitting cold turkey can lead to uncomfortable symptoms like anxiety, insomnia, and muscle pain, so having a structured plan in place is key. Knowing how to get off kratom safely can make all the difference in your recovery journey, and seeking help from a detox center or treatment program can provide the tools and support needed for long-term success.
Inpatient vs. Outpatient Rehabilitation
Inpatient (Residential) Rehab: Provides structured, immersive treatment for those with severe addiction or unstable home environments12
Outpatient Rehab: Allows individuals to receive treatment while maintaining work, school, or family responsibilities1218
Ongoing Therapy and Support
Individual counseling: Addresses personal triggers, trauma, and co-occurring mental health issues12
Family therapy: Improves communication and healing within the family system12
12-step programs (e.g., Opiate Anonymous): Offers peer support and accountability912
Sober living homes: Provide a drug-free, supportive environment during early recovery12
Relapse Prevention
Relapse is common in addiction recovery but does not signify failure9. Effective relapse prevention includes:
Identifying triggers: Stress, social situations, or emotional distress912
Developing coping skills: Stress management, mindfulness, and healthy hobbies12
Building a support network: Friends, family, therapists, and peer groups912
Regular follow-up: Ongoing check-ins with healthcare providers12
Seeking Help: When and How
If you or someone you know is struggling with opiate use, seek help as soon as possible. Warning signs that professional intervention is needed include:
Inability to stop using despite repeated attempts94
Neglect of personal, work, or family responsibilities94
What to Do:
Contact a healthcare provider: Addiction specialists or mental health professionals can assess the situation and recommend treatment84.
Call a helpline: National helplines provide free, confidential support and referrals.
Reach out to local resources: Community health centers, hospitals, and nonprofit organizations often provide addiction treatment services.
Conclusion
Learning how to quit kratom safely is crucial for anyone struggling with dependence on this powerful substance. Quitting kratom abruptly can lead to withdrawal symptoms such as anxiety, insomnia, nausea, and muscle pain, which is why many people benefit from a gradual tapering process and professional support. Understanding how to quit kratom involves more than just stopping use—it includes creating a plan, addressing the emotional and psychological aspects of addiction, and seeking guidance from medical professionals or addiction specialists. With the right resources and support system, overcoming kratom dependence is entirely possible.
While kratom is often marketed as a natural remedy for pain, anxiety, and opioid withdrawal, it carries significant risks of dependence and addiction. What may begin as occasional use can quickly evolve into a cycle of tolerance, withdrawal, and compulsive behavior. Recognizing the signs and symptoms—both physical and psychological—is essential for early intervention. Withdrawal from kratom can be uncomfortable and, in some cases, debilitating, making professional detox and support crucial for a safe recovery. As awareness grows, it's important to approach kratom with caution and seek help if use begins to interfere with daily life or overall well-being. Recovery is possible, and with the right guidance, individuals can break free from kratom dependence and regain control of their lives.
If you or a loved one is seeking compassionate, professional support on the journey to recovery, Solace Health offers personalized addiction services—from detox coordination to sober coaching—tailored to meet your unique needs. Let our experienced team help guide you toward lasting healing and freedom.
Sources:
Kratom - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK585120/
Understanding Kratom Use: A Guide for Healthcare Providers - Frontiers in Pharmacology
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.801855/full
Kratom withdrawal: Discussions and conclusions of a scientific ... - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC10311168/
Kratom: Unsafe and ineffective - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/prescription-drug-abuse/in-depth/kratom/art-20402171
Chemical composition and biological effects of kratom (Mitragyna speciosa) - Nature
https://www.nature.com/articles/s41598-020-76119-w
A Case Report of Kratom Addiction and Withdrawal - WMJ
https://wmjonline.org/wp-content/uploads/2016/115/1/49.pdf
Kratom Withdrawal Symptoms, Timeline & Detox Treatment - American Addiction Centers
https://americanaddictioncenters.org/kratom/withdrawal
Assessment of Kratom Use Disorder and Withdrawal Among an Online Convenience Sample of US Adults - PMC
https://pmc.ncbi.nlm.nih.gov/articles/PMC9402806/
Kratom safety and toxicology in the public health context - Frontiers in Pharmacology
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1403140/full
FDA and Kratom
https://www.fda.gov/news-events/public-health-focus/fda-and-kratom
Assessment of Kratom Use Disorder and Withdrawal among an ... - Johns Hopkins
https://pure.johnshopkins.edu/en/publications/assessment-of-kratom-use-disorder-and-withdrawal-among-an-online-
Kratom Use Disorder Experts Propose Decision-Making Algorithm ... - Johns Hopkins Medicine
https://www.hopkinsmedicine.org/news/articles/2025/02/emerging-use-of-kratom-in-us-kratom-use-disorder-experts-propose-decision-making-algorithm-for-clinicians
Kratom addiction per DSM-5 SUD criteria, and withdrawal: Prevalence and correlates in a cross-sectional survey - Drug and Alcohol Dependence
https://www.sciencedirect.com/science/article/abs/pii/S0376871624002503
Beneficial and adverse health effects of kratom (Mitragyna speciosa) - Toxicology and Applied Pharmacology
https://www.sciencedirect.com/science/article/abs/pii/S0278691524004794
